British Air Force Typhoon jets have conducted a mission with France's air force in a combined operation on an subterranean weapons facility in Syrian territory used by the IS group, as stated by the UK's MoD.
The site, located using intelligence, was believed to be containing munitions and bombs, the statement said, and was located in hills just above the historic site of Palmyra in Syria's central region.
"Our fighter planes utilized Paveway IV guided bombs to strike a several entry passages providing entry to the site... initial indications indicate the objective was successfully hit," the MoD said.
There was no indication of any harm to civilians in the operation late on Saturday and each participating jet returned safely, the ministry further stated.
The Typhoon FGR4s were assisted by a Voyager aerial refuelling aircraft.
The Islamic State group - alternatively referred to as Daesh - imposed jihadist rule over significant areas in Syria and Iraq prior to its 2019 collapse.
"This operation demonstrates British leadership, and resolve to operate in unison with our partners, to eliminate any resurgence of Daesh and their violent and radical beliefs in the Middle East," Britain's Defence Chief the Defence Secretary remarked.
British military aircraft have carried out overwatch operations over Syrian airspace to "prevent any attempted resurgence" of Islamic State subsequent to its routing at the Baghuz confrontation in 2019, the authorities noted.
"I extend gratitude to all the members of the UK armed forces participating in this mission for their professionalism and their valour," Healey said. "Including them were numerous British troops on duty over the festive period. This operation, to remove dangerous terrorists who endanger our safety, shows how our armed forces are always on standby, throughout the year, protecting the UK at home and powerful internationally."
During December, the American forces executed what it described as a "major assault" on Islamic State objectives in Syria, subsequent to an ambush claimed the lives of two US servicemembers and a civilian linguist in Palmyra.
The United Nations estimates Islamic State still has an estimated 5,000 to 7,000 militants in Iraq and Syria.